AustralieFrV1, Main, Exploration, bibRecord, 00D039

Evaluation of sorivudine (BV-araU) versus acyclovir in the treatment of acute localized herpes zoster in human immunodeficiency virus-infected adults

Identifieur interne : 00D039 ( Main/Exploration ); précédent : 00D038; suivant : 00D040

Evaluation of sorivudine (BV-araU) versus acyclovir in the treatment of acute localized herpes zoster in human immunodeficiency virus-infected adults

Auteurs : N. J. Bodsworth [Australie, Royaume-Uni, Canada, Pays-Bas, France, Belgique, Nouvelle-Zélande, États-Unis] ; F. Boag ; D. Burdge ; M. Genereux ; J. C. C. Borleffs ; B. A. Evans ; J. Modai ; R. Colebunders ; M. Thomas ; D. Dehertogh ; L. Pacelli ; J. Thomis

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 1997.

RBID : Pascal:97-0364526

Descripteurs français

Pascal (Inist)
- Virus immunodéficience humaine, Virus varicelle, Sorivudine, Antiviral, Activité biologique, Efficacité traitement, Toxicité, Chimiothérapie, Homme, Zona, Infection opportuniste.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antiviral, Biological activity, Chemotherapy, Herpes zoster, Human, Human immunodeficiency virus, Opportunistic infection, Sorivudine, Toxicity, Treatment efficiency, Varicella zoster virus.

Abstract

The clinical efficacy and safety of sorivudine as treatment for acute cutaneous zoster in human immunodeficiency virus-infected adults was compared with that of acyclovir in a double-blinded randomized study. A total of 125 patients with laboratory-confirmed zoster rash present for <72 h were assigned treatment with either 40 mg of sorivudine once daily or 800 mg of acyclovir five times daily, both taken orally for 7 days. Patients were assessed daily until all lesions crusted and then monthly for 6 months for postherpetic neuralgia (PHN) and for 12 months for recurrent or new episodes of zoster. Sorivudine significantly shortened the median period of new vesicle formation from 3.0 to 4.0 days (log rank P =.0001). Sorivudine was effective regardless of duration of rash before treatment. Zoster recurrences and new episodes were experienced by fewer patients assigned sorivudine (11%) than acyclovir (26%, P =.037). No differences were seen in incidence, severity, or duration of either acute neuritis or PHN. Both treatments were well tolerated.

Affiliations:

Australie, Belgique, Canada, France, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, États-Unis
Angleterre, Connecticut, Grand Londres, Nouvelle-Galles du Sud, Utrecht (province), Île-de-France
Londres, Paris, Sydney, Utrecht

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Le document en format XML

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<term>Human</term>
<term>Human immunodeficiency virus</term>
<term>Opportunistic infection</term>
<term>Sorivudine</term>
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<term>Antiviral</term>
<term>Activité biologique</term>
<term>Efficacité traitement</term>
<term>Toxicité</term>
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<front><div type="abstract" xml:lang="en">The clinical efficacy and safety of sorivudine as treatment for acute cutaneous zoster in human immunodeficiency virus-infected adults was compared with that of acyclovir in a double-blinded randomized study. A total of 125 patients with laboratory-confirmed zoster rash present for <72 h were assigned treatment with either 40 mg of sorivudine once daily or 800 mg of acyclovir five times daily, both taken orally for 7 days. Patients were assessed daily until all lesions crusted and then monthly for 6 months for postherpetic neuralgia (PHN) and for 12 months for recurrent or new episodes of zoster. Sorivudine significantly shortened the median period of new vesicle formation from 3.0 to 4.0 days (log rank P =.0001). Sorivudine was effective regardless of duration of rash before treatment. Zoster recurrences and new episodes were experienced by fewer patients assigned sorivudine (11%) than acyclovir (26%, P =.037). No differences were seen in incidence, severity, or duration of either acute neuritis or PHN. Both treatments were well tolerated.</div>
</front>
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Evaluation of sorivudine (BV-araU) versus acyclovir in the treatment of acute localized herpes zoster in human immunodeficiency virus-infected adults

Evaluation of sorivudine (BV-araU) versus acyclovir in the treatment of acute localized herpes zoster in human immunodeficiency virus-infected adults

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri